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Synchronous and sequential regimens have not been compared in randomized clinical trials, and such trials would be extraordinarily difficult to design.
Although local intra-arterial fibrinolysis (LIF) using recombinant tissue plasminogen activator (rtPA) is a promising treatment, outcomes have not been compared in randomized trials.
It seems as efficient as NBCA, although it has never been compared in randomized trials.
Although the two groups of agents have not been compared in randomized studies, attenuated androgens appear to be more effective.
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Similarly we did not include studies that reported the cost-difference (or cost effectiveness difference) between alternative drug regimens whose efficacy was being compared in randomized controlled trials.
Two procedures have been compared in two randomized cross-over consecutive periods of one day each (3 oral cares a day)—on 1 day, they received routine oral care (oral care (O) then tracheal suction (T)) and on the other day they received optimized oral care (subglottic suction (SG1) then O then SG2 then T).
Different dietary strategies to promote weight loss have not directly been compared in a randomized, long-term study.
Immunogenicity and safety of the HPV-16/18 HPV-16/18/11/16/18 vandines have been compared in a randomized, observaccinesd study in havethy women aged 18–45 y (study HPV-010; NCT00423046).
These graft sources have never been compared in a randomized fashion, and the optimal graft source for patients without a fully matched related donor or MUD is uncertain.
Since then, both approaches have been compared in more than 30 randomized controlled trials.
So far, succinylcholine and rocuronium have not been compared in an adequately powered randomized trial in intensive care.
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