However, traditional meta-analyses can compare only two treatments (or classes) that have been compared in head-to-head trials [ 9].
Typically, only a few of all possible drug combinations will have been compared in head-to-head randomized clinical trials, and perhaps equally infrequent, most individual drugs and drug combinations cannot be compared indirectly.
However, their comparative diagnostic accuracy has not been compared in large head to head trials.
Network meta-analysis (NMA) allows for the comparison of multiple treatments in a comprehensive analysis and the determination of the best treatment among several competing treatments, including those that have never been compared in a head-to-head study.
51 They conducted a Bayesian network meta-analysis to combine the available randomized controlled trials in order to compare treatment effects that had not been compared in a head-to-head fashion before, and to account for the study heterogeneities of included trials.
In A. gambiae, mRNA levels of twenty "classic" OBPs have been compared in antennae (or heads) of male and female by microarray hybridization and quantitative RT-PCR after normalization by a ribosomal protein (RpS7), and several transcripts displayed significant enrichment in one or the other sex [29].
The efficacy and safety of these two EGFR-targeted mAbs has recently been compared in ASPECCT, the first head-to-head monotherapy study of Q2W panitumumab versus QW cetuximab in patients with KRAS exon 2 WT, chemorefractory mCRC [ 41].
Two FUT8 and GMD siRNA-introduced clones, FG1 and FG16, and their parental IgG1-producing clone, CHO/DG44 32-05-12, were adapted to serum-free medium, and the performance of the fed-batch cultures was compared in a head-to-head analysis (Fig. 3A, 3B).
Letrozole and anastrozole are currently being compared in a large randomized head-to-head trial in early breast cancer (ClinicalTrials.gov identifier NCT00248170) [ 120].
&: Odds ratio replaced with interstitial lung fibrosis group; ‡: Odds ratio replaced with non-interstitial lung fibrosis group Allele frequencies of TNF-α gene were compared in SARS patients between femoral head necrosis and non-femoral head necrosis (Table 7).
The irreversible ErbB family blocker afatinib and the reversible EGFR tyrosine kinase inhibitor gefitinib were compared in the multicenter, international, randomized, head-to-head phase 2b LUX-Lung 7 trial for first-line treatment of advanced EGFR mutation positive NSCLCs.
