This is because AD is classically recognized as a disease of memory, and indeed memory-related brain regions have long been known to be affected in the course of disease (Walsh et al, 2002; Chhatwal & Sperling, 2012).
Based on these clinical experiences, the so-called meridians have been classically recognized and described [ 1].
The only other high loading of Factor 2 is on the Profiling Elements of Prosodic Systems Child version focus output test, which involves control of prosody in speech production, but is not classically recognized as a phonological skill in the same sense as the other four variables.
Although classically recognized as a marker of differentiation [ 40, 45], CD26 expression has recently been reported to define a metastatic subpopulation of CICs within CRC and associated with development of metastasis in CRC patients [ 14, 21].
However, although classically recognized as a component of the methionine biosynthesis pathway, recombinant MetC from wBm was recently shown to have in vitro non-canonical L-alanine racemase activity [ 83] and likely has a role in peptidoglycan synthesis in Wolbachia.
Although not classically recognized as an intracellular pathogen, uropathogenic E. coli exhibit enhanced macrophage survival relative to non-pathogenic strains, which may facilitate intracellular persistence.
