Thus far, only a few direct target genes bound by STAT5, such as CISH, PIM1, ID1, and BCLXL, have been characterized in the erythroid lineage (Dumon et al., 1999; Matsumoto et al., 1997; Mui et al., 1996; Wood et al., 2009).
Myelodysplastic syndrome (MDS) with chromosome 5q deletion is characterized by erythroid hypoplasia arising from lineage-specific p53 accumulation resulting from ribosomal insufficiency.
In mammals, the ABC-family transporter protein Abcb10 forms a complex with mitoferrin-1 and increases iron import into mitochondria, as recently characterized in erythroid tissue [ 6].
The first half of the expansion and differentiation was characterized by cluster-like colonies of erythroid cells and sparse loose-lying cells (Fig. 1b, c).
TF-1 cells were cultured in presence of EPO and their erythroid phenotype was characterized.
Homogeneous erythroid cells were characterized by cell morphology, flow cytometry, and hematopoietic colony assays.
Early erythroid cells are characterized by an increased expression of FHL2 (GNF Expression Atlas 2 Data from U133A and GNF1H Chips; http://www.genome.ucsc.edu).ucsc.edu
For KLF10 or KLF16, although the identified erythroid-specific or putative erythroid-specific DHSs in their genomic regions activated minP in K562 cells, no enhancer activating KLF-Ps was characterized, reflecting that DHSs identified in their genomic regions may work as promoter-specific enhancers.
The patient was characterized by refractory anemia, dysplasia of the megakaryocytic and erythroid lineage, as well as myeloid hyperplasia with excess blasts (RAEB-T) with megakaryocytic phenotype.
Hematopoietic ontogeny is characterized by overlapping waves of primitive, fetal definitive, and adult definitive erythroid lineages.
