The type 1 parathyroid hormone receptor (PTH1R) offers unique insight into both the opportunities and challenges of exploiting ligand bias in pharmaceutical design, not only because numerous "biased" PTH analogs have been described but also because many of them have been characterized for biological activity in vivo.
There are other IFN-γ-induced genes that have not been characterized for bactericidal activity, and in addition to IDO may be required for the full manifestation of the anti-chlamydial function of this cytokine.
We also chose for molecular validation the transcription factor AFT1, a protein that has been characterized for its activity in low levels of iron as a regulator of the iron-scavenging genes emerging from our original RNA-seq analysis (Shakoury-Elizeh et al. 2004).
Cocaine-mediated behaviors in the 129S1 strain have not yet been reported; however, several other 129 substrains have been characterized for cocaine locomotor activity with mixed results [ 21, 25, 27- 29].
Various species of Artemisia have been characterized for their biological activities.
In addition to SSs isolated from members of the genus Bupleurum that exhibit pharmacological activity, several other groups of secondary metabolites with relevant biological activity have been characterized, for example, polysaccharides with anti-ulcer activity and lignans with anti-proliferative activity [ 68].
However, the antimicrobial activity has been characterized for only one of these ABFs, ABF-2.
Indeed, removal activities have been characterized for most of the modifications known.
First, PQQ-dependent dehydrogenases of both soluble and membrane-bound type were characterized for their activity toward various DERA-derived lactols.
All specimens were characterized for G6PD activity in duplicate with the quantitative G6PD kit from Trinity Biotech (catalog number 345-B; Trinity Biotech PLC, Bray, Ireland) according to the manufacturer's instructions as the reference assay for all testing.
