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Lateral DNA transfer events and their inheritance has been challenging to document.
Yet, the adaptive benefit of these intermediates and the anthocyanin pigments themselves have been challenging to document [12], [48], [49].
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A path to a successful product can be difficult to follow and related decision-making processes can be challenging to document.
Since many patients attending EDs have already commenced oral antibiotic treatment, particularly in areas with developed primary care services, it will also be challenging to document objective clinical progression when the patient is being treated by a different practitioner.
The scope of heparanase function has recently been challenged by evidence documenting its ability to activate signaling molecules (i.e., Akt, p38, Src) in an enzymatic-independent manner, resulting in enhanced gene transcription [42], [47] and cell adhesion [26] [28].
There are challenges to issuing refugee travel documents today, but they are surmountable.
This is challenging as a document which is primarily designed to offer legal protection will be markedly different to a document aimed at protecting trial participants through enabling them to make an autonomous choice.
Reichsorchester was made in 2007, when the challenge to document what happened still seemed urgent.
"The United States must maintain its ability to project power in areas in which our access and freedom to operate are challenged," the strategy document said.
Extracting semantic relationships between entities from text documents is challenging in information extraction and important for deep information processing and management.
Previously, obtaining such information apart from official reports and documents was challenging.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com