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It has been challenging to develop a generalized algorithm to effectively trace both types of chemical plumes due to the significant differences of their kinetic and dynamic properties.
Given the high homology between the protein lysine methyltransferases G9a-like protein (GLP) and G9a, it has been challenging to develop potent and selective inhibitors for either enzyme.
It has been challenging to develop and establish effective regimens because clinical experience in pediatric PTCL is sparse and individual studies are hampered by too few patients.
This is primarily because it has been challenging to develop MRI protocols that adequately visualise the deeply located and complex structure of the hip joint in three-dimensional analyses.
Due to the lack of a druggable domain, it has been challenging to develop small molecule inhibitors that target MYC itself, or disrupt MYC-mediated protein-protein or protein-DNA interactions [ 6, 7].
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As a result, the scientific community has been challenged to develop new and innovative approaches to understand the disease progression and to design better therapies.
Companies like Cruise and Waymo with large numbers of autonomous vehicles have been challenged to develop self-driving cars that can safely navigate complex urban environments and fit in with the millions of human drivers on the road.
Deconvoluting cellular H2S generation, translocation, and metabolism steps is difficult, however, and chemists have been challenged to develop more accurate experimental methodologies for observing these processes.
So it could be challenging to develop drugs that can hurt tumors but not normal cells.
However, since the targeted SCK is challenging to develop, it is also inappropriate to spend too little time on it.
PPDM algorithms are challenging to develop and computationally intensive to execute.
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been difficult to develop
been challenging to sustain
been challenging to retrieve
been seeking to develop
been challenging to use
been challenging to be
been challenging to link
been challenging to promote
been challenging to maintain
been challenging to scale
been challenging to remove
been working to develop
been challenging to watch
been challenging to assess
been challenging to keep
been challenging to balance
been challenging to carry
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com