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The cost-benefit ratio of having more than one cambium might be the answer, although this has not been calculated to date, unless disadvantages as yet unknown to us would impede evolutionary spread of growth by more than one cambium.
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Person-years of observation were calculated to the date PALGA follow-up ended (June 2007), date of ovarian cancer diagnosis or date of death, whichever came first.
Survival time was calculated to the date of death and censored on date last known alive.
Time to progression was calculated to the date of progression or death and censored on date last known alive.
Disease-free survival (DFS) was calculated to the date of disease recurrence or death from any cause.
In cases of PR, treatment response time was calculated to the date at which the enhanced tumor stopped becoming smaller.
From Arrhenius plot, the expiration date was calculated to be about 4.366 years.
The median follow-up from the study start to end dates was calculated to be 5 years (IQR=2 10 years).
Time to follow-up was calculated as interview date to date of death or date censored (31 December 2007).
PFS time was calculated from baseline date to the date of first reported PD.
OS time was calculated from baseline date to the date of death.
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CEO of Professional Science Editing for Scientists @ prosciediting.com