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Most knowledge concerning CD4+ responses to EBV has been built on observations from either healthy EBV carriers or in vitro experiments.
This hypothesis has been built on observations that, firstly, lysosomal integrity is disturbed during the apoptotic process with concurrent release of the lysosomal content into the cytosol (Guicciardi et al, 2000; Foghsgaard et al, 2001; Kagedal et al, 2001; Mathiasen et al, 2001; Neuzil et al, 2002).
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This ability is based on "folk physics", an understanding of the physical world that develops naturally in human infants and is built on observation of and experimentation with regularities in the physical world, which extend and/or confirm innate predispositions or core beliefs (Baillargeon 1994; Povinelli 2000; Spelke 2000; Baillargeon 2002; Carey 2009; Johnson 2010).
Entire careers have been built on it".
The Tobit model was built on 120 observations through 2006 because the information on health financing, one of the independent variables, was available only through that year at the time of the analysis (2009).
The former are built on empirical observations which, as of yet, are far from complete.
Either introducing the virtual/ideal service models as reference systems [8, 9] or defining some key metrics as criteria [11 14], many existing algorithms are built on the observation, judgement, intuition, and experience of the designers.
It is built on the observation that chlorophylls a and b in green leaves strongly absorb light in the Red while the cell walls strongly scatter light in the NIR region [88].
The first prediction methods were built on the observation that there is a strong positive correlation between the popularity of a web content at different stages during its lifetime [28],[28].
Our proof is built on an observation that the general step of the OMP process is in essence the same as the initial step in the sense that the residual is considered as a new measurement preserving the sparsity level of an input vector.
After all, every one of us is a continuation of what has become before us; and, every new piece of knowledge is built on former observation and expertise.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com