Sentence examples for been broadly implicated in from inspiring English sources
BACKGROUND The prefrontal cortex plays a critical role in regulating emotional behaviors, and dysfunction of prefrontal cortex-dependent networks has been broadly implicated in mediating stress-induced behavioral disorders including major depressive disorder.
Natural antisense transcripts (NATs) have been broadly implicated in regulating gene expression and chromosome structure [29] [34].
Decreased expression of Ppara has also been observed in aging heart, liver, and kidney [72] and recently it has been broadly implicated in aging and systemic inflammation [73].
In summary, disruption of the homeostatic balance between proliferation and apoptosis has been broadly implicated in cancer and silibinin tips the balance away from development of colorectal cancer.
Additionally, GH has been broadly implicated in aging and neurogenesis, as neural precursor cells in the subventricular zone proliferate in response to central GH infusion [ 12].
The interconnected HSP70 and HSP90 cytosolic chaperone systems (Kampinga and Craig, 2010; Hartl et al., 2011) have been broadly implicated in folding-dependent trafficking of CFTR and hERG (Loo et al., 1998; Ficker et al., 2003).
In addition to effects on eicosanoid metabolism TGM2 also activates the transcription factor NFκB that is broadly implicated in the generation of pro-inflammatory cytokines in asthma and other inflammatory diseases, and induces iNOS via NFκB [42].
Finally, integrins are broadly implicated in bone metastasis due to their ability to induce mitogenic intracellular signaling.
These small interfering RNAs are broadly implicated in viral infection of mammalian cells, with either positive or negative effects on viruses' replication.
The paralog PIK3C-γ or PIK3CG is broadly implicated in many diseases due to its role as a downstream signaling component of chemokine receptors that modulate inflammatory pathways [ 12].
Th17 cells, a recently discovered subset of T helper cells with a highly inflammatory nature, can secrete several potent proinflammatory cytokines, including IL-17A and IL-17 F, and are broadly implicated in inflammatory and autoimmune diseases [ 7- 9].
