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MAP kinases, including ERK, p38, and JNK, have been broadly implicated as regulators of cell proliferation and migration in diverse cell types in response to a variety of stimuli [ 42- 44].
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Additionally, GH has been broadly implicated in aging and neurogenesis, as neural precursor cells in the subventricular zone proliferate in response to central GH infusion [ 12].
Deregulation of microRNAs has been broadly implicated in the inactivation of tumour-suppressor genes and activation of oncogenes in HCC.
Natural antisense transcripts (NATs) have been broadly implicated in regulating gene expression and chromosome structure [29] [34].
Decreased expression of Ppara has also been observed in aging heart, liver, and kidney [72] and recently it has been broadly implicated in aging and systemic inflammation [73].
Although published data implicates non-canonical Wnt signalling as a positive regulator of cell migration [ 30, 32, 33], DLG1 has been broadly implicated in maintaining integrity of the epithelium, aberrations of which are responsible for certain human diseases [ 34, 35].
The paralog PIK3C-γ or PIK3CG is broadly implicated in many diseases due to its role as a downstream signaling component of chemokine receptors that modulate inflammatory pathways [ 12].
Finally, integrins are broadly implicated in bone metastasis due to their ability to induce mitogenic intracellular signaling.
Temperature has been broadly considered as a major determining factor.
And then the term "distribution" is broadly defined, as well.
These clouds have been implicated as possible harbingers of permanent changes in the upper atmosphere.
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