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Physical activity is notoriously difficult to measure and the self reported assessment could have been biased by knowledge of the treatment allocation.
This method ensured that at least one of the outcome measures is unlikely to have been biased by knowledge of DUP or other baseline factors.
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Nevertheless, total deaths, the main outcome of the study, could not be biased by knowledge of the exposure.
The physician review process is biased by knowledge of outcome severity and by our natural and variable inclinations to find fault [ 25, 26].
The less information that is accessible, the less chance there is of recruitment being biased by knowledge of the likely allocation of future patients.
Participants could not be blinded to treatment allocation, and the higher self reports of activity in the physical activity group compared with the control group may be biased by knowledge of allocation.
However, it is important to note that this was an open-label, non-randomized, dose-adjustment study and the extent to which raters may have been biased by their knowledge of medication cannot be assessed [ 84].
Our study may have been biased by the fact that migrants with poor knowledge of German were underrepresented in the sample population.
CT scans have thus helped scientists and Egyptologists to increase their knowledge, which had hitherto been biased by the cultural stereotyping of Egypt in classical sources.
Consequently the parties' judgments are biased by their knowledge of their circumstances and are insufficiently impartial.
Data collection might be biased by this knowledge.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com