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The specific targeting of the ERK1/2 pathway to treat cancer has been best studied using MEK1/2 inhibitors (reviewed in [ 48]).
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These efforts have brought the axolotl closer to becoming a genetic model organism, that is, a model that can be used to identify genes for phenotypes that are best studied using the axolotl.
Catchment-scale impacts are best studied using a water balance model, which would require a basic level of field data and understanding of the variability.
Out of this flux has emerged the dynamical concept, according to which cognitive processes are the behavior of nonlinear dynamical systems and are best studied using the mathematics of dynamical modeling and dynamical systems theory.
While we see an association, it doesn't address causation, which is best studied using a longitudinal and not a cross-sectional design.
These conditions are relatively rare and hence are best studied using clinical databases or disease registries.
The healing of sclerotomies is best studied using ultrasound biomicroscopy [ 3, 4].
Conditions with such a low incidence are best studied using large high quality clinical databases arising from multicentre audits or disease registries [ 8- 10].
These objects are often best studied using infrared spectroscopy.
The complex nature of protein signaling networks, such as apoptotic pathways, with multiple variables acting at the same time, can be often best studied using a systems level analysis.
Yeast such as S. boulardii are best studied probiotics being used successfully and well known to play a crucial role in the treatment and management of diarrhoea and inflammatory bowel disease and to reduce the duration of disease.
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