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Because head-to-head comparisons of AEDs (used in the European Union to approve drugs for monotherapy) have not shown substantial differences in efficacy between drugs, FDA approval for use of an AED as monotherapy has typically been based on trials with novel designs that have been criticised for reasons of ethics and clinical relevance.
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As a result, previous particle damper designs have been based on trial-and-error experimentation.
In high-pressure processing (HPP), equipment design has largely been based on trial-and-error experimentation.
The positive results described here are based on trials in one industry.
To be included, meta-analysis should be based on trials in the field of hepatology and published as full papers before 2000.
More exceptionally, all traditional drug delivery methods are based on trials and errors.
All analyses (behavioral and fMRI) are based on trials with correct preference responses.
Current guidelines for the antimicrobial therapy of melioidosis are based on trials conducted in adult patients.
However, these treatments are based on trials which generally exclude patients with CKD.
However, the results presented here are based on trials conducted at a single experimental site with a single fertilization treatment.
To date, most large-scale safety assessments of adalimumab are based on trials of patients with RA.
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