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The anti-arrhythmic effect of K201 has been attributed to reducing the open probability of RyR2 thus preventing excessive diastolic SR mediated Ca2+ leak [ 26].
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Some proposed mechanisms leading to the change in PEH have been attributed to reduced peripheral vascular resistance, 18 reduced sympathetic activity, 18, 19 diminished systolic volume, 18 and changes in the sensitivity of adrenergic cardiac and endothelial factors.
Importantly, memory retrieval is likewise acutely impaired under sleep deprivation, which has been attributed to reduced source and reality monitoring [18], [20] [22], and the same mechanisms may also acutely support the generation of false memories.
The reduced calcium absorption has been attributed to reduced circulating 1,25-dihydroxyvitamin D levels, and to gastrointestinal resistance to the action of 1,25-dihydroxyvitamin D [ 20].
Reduced adiposity of the SCD-knock out mouse has been attributed to reduced lipid biosynthesis and increased lipid oxidation [ 90], while increased SCD in obese subjects seems to favor lipid storage [ 91- 93].
This BRD associated weight loss has been attributed to reduced feed intake due to anorexia and depression and to the increased protein and caloric cost of a febrile response and (chronic) inflammation [ 40- 44].
On linear regression analysis, the reduction in aortic PWV was attributed to reducing the BP.
The effectiveness of CT in the treatment of hypercalcemia is attributed to reducing osteoclast activity [ 19].
The effect of AnTc on revertant yield seen above was attributed to reducing the number of cells in the pregrowth culture that have coamplified with lac and with tetA genes.
These beneficial effects of HS may be attributed to reducing the plasma concentration of NO and IL-1β as well as the organ O2- level and decreasing lung PMN infiltration and liver necrosis, and thus decreasing the mortality rate in peritonitis-induced septic animals.
Our results indicate that low rate of reproduction in captivity can be attributed to reduced male reproductive fitness.
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