A significant proportion of the phenotypic variation in any organism can be attributed to polymorphisms at the DNA level.
These person-to-person differences, which are attributed to polymorphisms in the genes encoding for the respective enzymes, might define subpopulations of women with higher lifetime exposure to hormone-dependent growth promotion, or to cellular damage from particular oestrogens and/or oestrogen metabolites.
Thus, such disparities in sensitivity to vitamin D may be attributed to polymorphisms in the VDR gene.
Since most of the Nicotiana spp nucleotide entries in GenBank correspond to N. tabacum, a percentage of the mismatches may be attributed to polymorphisms in the 3' UTR of mRNAs from N. attenuata and this tobacco species.
Currently, it is thought that hotspot diversity in natural human populations can be attributed to polymorphism of the Prdm9 ZFA.
Furthermore, the different populations, the Asian and European, might well constitute a reason behind these contrasting clinical outcomes; in particular, distinct profiles of response and tolerability have often been attributed to genetic polymorphisms involved in drug metabolism and chemosensitivity [33], [34].
In the Ras-induced skin squamous carcinoma model, the low susceptibility of the C57Bl/6 strain and the high susceptibility of the FVB/N had been attributed to a polymorphism in the Ptch gene [36].
Variation between virulent and avirulent phenotypic phases in B. pertussis has been attributed to a polymorphism within an HPT located in the coding region of the virulence regulatory sensor kinase gene, bvgS [ 24].
Although to date, no functional role has been attributed to STAT3 rs744166 polymorphism, in this study, the expression of STAT3 mRNA was significantly higher in stimulated PBMCs from a group of healthy volunteers, carrying the GG genotype, than from those carrying AG or AA genotype.
