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This insulin-dependent phosphorylation has been attributed to activation of the mitogen-activated protein kinase (MAPK) pathway, involving serine residues contained within the N-terminal ligand-independent activation domain (AF-1) of PPARα [23] and PPARγ [22].
The main components of marijuana including the tetrahydrocannabinol Δ-THC (1, Fig. 1) and other phytocannabinoids have long been known to exhibit analgesic activity, which has since been attributed to activation of the CB1R as well as the CB2R.
Although cellular effects of 1,25(OH)2D3 traditionally have been attributed to activation of a nuclear vitamin D receptor (VDR), a novel receptor for 1,25(OH)2D3 called 1,25D3-MARRS 1,25D3-MARRSsociated, rapid response steroid-binding) protein was identified recently.
Although the anti-parkinsonian action of SKF83959 has been attributed to activation of PI-linked D1-like receptor [1], [8], [9], [11], the exact mechanisms underlying the action remain unclear.
Upregulation of MAFbx and MuRF1 has been attributed to activation of FOXO1 [ 13, 14].
Antiproliferative and apoptotic effects of Cisplatin have been attributed to activation of ERK in various cell lines [ 37].
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This was attributed to activation of Nrf2-ARE pathway, reduced NF κB activity, and increased oxygen availability via HIF1 signaling mechanisms.
It potentially could be attributed to activation in S1 and S2 and recorded together, since both are activated by noxious stimuli [13].
Taken together, these results indicate that autophagy induced by silencing of EEF2K is attributed to activation of AMPK-ULK1 pathway, independent of the suppression of MTOR activity and stimulation of ROS production.
On the basis of electrochemical and spectroscopic results, the current wave is attributed to activation of a catalytic mechanism of H2O2 reduction involving copper species.
Collectively, suppression of KEAP1 expression in human NSCLC cells resulted in sensitization to chemotherapeutic agents, which may be attributed to activation of PPARγ and subsequent alterations in cell differentiation and CSC abundance.
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