This study was designed to examine whether the NASH-associated increase in hepatic TNF-α mRNA expression and serum TNF-α, and decrease in hepatic PPARα mRNA expression in rats secondary to 12-week consumption of a high-fat diet would be attenuated with concurrent exercise.
We found that exercise effects on SHBG and estradiol change were attenuated with adjustment for total and percent body fat change and somewhat attenuated with adjustment for intra-abdominal fat change.
These benefits of isolated resistance exercise are attenuated when resistance exercise is combined with aerobic exercise and compared to aerobic exercise alone.
The glycemic response to a standardized meal was reduced by metformin, but the reduction was attenuated when exercise was added (metformin × exercise interaction, P = 0.05).
In addition, there was an age-associated increase in skeletal muscle TRF1 protein levels that was attenuated by exercise.
Indeed, it has been demonstrated that ventricular performance is attenuated following strenuous exercise, a phenomenon that has been designated "exercise-induced cardiac fatigue" (EICF) [ 4].
Previous research has shown that age differences in disability are attenuated by physical exercise [39].
In this study, carotid baroreflex-mediated reduction in leg vascular conductance to the sympathoexcitation was attenuated in the exercising leg compared with resting condition or the nonexercising leg.
Similarly, cumulative concentration-response curves to CCh (n=5) were attenuated due to the exercise, with reduction in Emax value from 100% (SED) to 74.1±5.4; 75.9±5.2; 62.9±4.6 and 89.7±3.4% in the groups exercised by 2, 4, 6 and 8 weeks respectively.
The reduction in VAT following exercise was attenuated in participants with T2DM (–3%) compared with participants who were non-T2DM (–18%, p<0.001 for the difference in change).
