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Other genetic mutations have been associated with profound behavioral changes.
Dexamethasone has been associated with profound immunosuppression (Hughes et al, 2005; Grossman et al, 2011) and it may severely limit a patient's ability to mount an antitumour immune response against the glioblastoma (Zitvogel et al, 2008a).
Interestingly, infection with C. rodentium has not been associated with profound changes in apoptosis.
Indeed, dexamethasone has been associated with profound immunosuppression and increased risk of infection 23.
Furthermore, acquisition of resistance has been associated with profound dysregulation of the epigenomic landscape, suggesting that epigenetic changes may be a driving force in acquiring resistance to anticancer agents (Baylin 2011; Glasspool et al. 2006).
The introduction of the MET into our institution has been associated with profound changes to cultural and medical practice that have affected the way in which the intensive care unit and the hospital view the roles of junior doctors, nurses, intensive care physicians, and senior doctors.
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Severe aggression is associated with profound changes in sleep architecture.
Cytotoxicity was associated with profound cell cycle checkpoint activation and apoptosis induction.
Not surprisingly, banking crises are associated with profound declines in output and employment.
Cocaine-use disorders are associated with profound abnormalities in sleep and sleep architecture.
Severe female aggression seems to be associated with profound changes in sleep architecture.
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