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For instance, members of the family of the serine protease autotransporters of the Enterobacteriaceae (SPATE) have been associated with pathogenic strains and are among the virulence proteins predominantly secreted by the pathogens of this family [ 4].
TNFα has been associated with pathogenic processes leading to CM [17].
Type III secretion system (TTSS), which has been associated with pathogenic mechanisms in a wide variety of bacteria, is now recognized as potential virulence factors of non-O1, non-O139 strains as well as V. parahaemolyticus [31] [33].
Ghrelin polymorphisms have been associated with pathogenic variations in plasma lipid concentrations, blood pressure, plasma glucose, and body mass index (BMI).
Although IL-12p40 has been associated with pathogenic inflammatory responses, there are meager studies done on the usage of IL-12p40 as a biomarker of inflammation due to exposure to air particles.
Indeed, while we found several socially structured taxa that have been associated with pathogenic effects (e.g., Fusobacterium spp, Campylobacter ureolyticus), we found several other bacteria thought to be beneficial to hosts.
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Toxin-antitoxin genes are often transferred through horizontal gene transfer and are associated with pathogenic bacteria, having been found on plasmids conferring antibiotic resistance and virulence.
Elevated plasma levels of cytokines in SIVmac251 infected animals provide additional evidence that immune activation is associated with pathogenic infection.
These results strongly suggest that an antibody response to brain antigens induced by P. falciparum infection may be associated with pathogenic mechanisms in patients developing CM.
Not surprisingly, many of the protein families we identified are likely to be associated with pathogenic processes such as plant cell wall degradation, toxin biosynthesis, formation of reactive oxygen species and detoxification [5].
In fact, MERRF has been previously reported to be associated with pathogenic mutations of the mitochondrial tRNAPhe gene [ 22].
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