The specific VDR polymorphisms chosen were based on previous published literature as they are associated with functionality.
5 8 In the UK, such systems are commonly referred to as electronic prescribing (or ePrescribing) systems and are associated with functionality surrounding prescribing, decision support at the point of care, transmission of prescribing-related information (eg, when ordering or monitoring), medicines administration, and use of data for secondary uses (eg, quality improvement).
In particular, schizophrenia with prominent positive or negative symptoms has been associated with lower functionality, health-related quality of life (HRQoL), and lost work days among caregivers, with greatest caregiver burden among patients with the highest symptomatology [ 9].
The use of nanofibers has also been associated with antibacterial functionality of graphene for applications in wound healing [ 3] and the development of methods for carbon nanotubes and carbon nanobelts via double needle electrospinning on a basis of water-in-oil emulsion technique [ 4].
In humans, low IGF-1 levels have been associated with frailty and decreased functionality [ 22] Although these candidate ageing/frailty biomarkers have been described in the geriatric field, their value in the clinical practice is far from established, and they have not formally been correlated with the frailty syndrome [ 23] in older cancer patients.
Recently, the phenomenon of "chemobrain" (long-term chemotherapy-induced cognitive impairment) has been described and has been associated with altered quality of life and functionality.
However, this has been associated with adding descriptive text to attribute functionality to existing gene structures rather than annotation of new gene structures.
In those duplexes, we have checked which features are associated with siRNA functionality.
The cluster of which CSNK1A1 was a member was associated with significant functionality in coated pit, endomembrane system, endocytosis, endosome, binding and transport activities.
Paraoxonase (PON1) enzyme activity is associated with HDL functionality.
