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The presence of dentinal defects has been associated with failures in periapical microsurgery and is likely part of the longitudinal progression of ROF.
In addition, Vitamin D deficiency has been associated with failures in achieve an SVR after antiviral therapy in genotypes 1 [ 94, 95], 2, and 3 [ 103] HCV infection in some cohorts, but not in others ([ 101, 103] for genotype 1; [ 100] for genotype 2-3).
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A negative outlook, yes, but these four fixtures have recently been associated with failure.
"Thin" modular polyethylene bearings have previously been associated with failure from wear.
Benign biliary strictures (BBS) are usually managed with plastic stents, whereas placement of uncovered metallic stents has been associated with failure related to mucosal hyperplasia.
Purpose: Bcl-2 and bax are proteins with opposing roles in apoptosis regulation; yet abnormal expression of either has been associated with failure after radiotherapy (RT).
Recently, bacterial load in patients with pneumococcal pneumonia has been associated with failure (likelihood of death) [22].
The rate of discontinuation of pump therapy in children and adolescents has been associated with failure to improve HbA1c [ 8].
Hedgehog signalling has been associated with failure to respond to chemoradiotherapy and also with increased incidence of tumour regrowth following treatment.
I think Reeve is right that there's a huge risk-averse mentality; part of it is a fear of litigation, and part of it is institutions and investigators who don't want to be associated with failures.
Unfortunately, these infections are associated with failures and high rates of relapse even when patients receive recommended therapy [5, 6].
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