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A hypoxic profile that included 13 genes such as VEGF and ANGPTL4, has been associated with distant metastases and might represent an independent predictor of outcomes in primary breast cancers [27].
Mesenteric adipose tissue has been associated with distant atherosclerosis, assessed by measurement of carotid intima thickness using ultrasound [5].
In addition, leptin has been associated with distant metastasis and short survival, suggesting that it may have a negative prognostic value [ 76, 77].
Notably, elevated expression of COX-2 in human breast cancer biopsies has been associated with distant metastases and poor prognoses (Ranger et al, 2004; Zerkowski et al, 2007).
Furthermore, over expression of HSP90B1, a heat shock protein regulated by CEBPB and found in Table 2, has been associated with distant metastases and decreased overall survival in breast cancer patients with otherwise good prognoses (Cawthorn et al., 2012).
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Microvessel density in NSCLC is associated with distant metastatic spread and poor survival [37].
A substantial divergence in the landscape of driver alterations was associated with distant appearance of a recurrent tumor from the initial tumor, suggesting that the genomic profile of the initial tumor can mislead targeted therapies for the distally recurred tumor.
Our study demonstrates that increased cyclin E expression is associated with distant metastases for whichever histological component of nephroblastoma it is assessed in.
Thirteen emm types are associated with distant STs: five emm types are associated with >two distant STs and eight emm types are found among a single pair of distant STs, whereas five emm types are associated with three or more distant STs (Table 4).
Low expression of AR is associated with distant metastasis in the AR-positive TNBCs [ 12].
Its expression was associated with distant metastasis and local progression [ 65].
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