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Acetate megestrol had been associated with compulsive eating and hypertriglyceridemia as a consequence of its orexigen effect.
Orbitofrontal function is known to be impaired in adults with cocaine dependence (58); specifically, disruptions in orbitofrontal functioning have been associated with compulsive features of stimulant drug dependence (59,60).
Elevated levels of manganese in blood, hair or nails have also been associated with compulsive behaviors, emotional lability, hallucinations, attention disorders, and cognitive decline in adults [ 18– 23] as well as Amyotrophic Lateral Sclerosis (ALS) [ 24].
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These mice required higher doses of ondansetron to reduce their compulsive-like alcohol-seeking behavior, suggesting that higher expression levels of the 5-HT3A subunit are associated with compulsive alcohol-seeking tendencies.
PWS has also been associated with obsessive-compulsive disorder.
Abnormalities in corticostriatal pathways, such as a relative reduction in prefrontal cortex gray matter and an increase in striatal volume, have been associated with impulsive and compulsive traits and have frequently been reported in stimulant-dependent individuals (14 19).
One SNP rs2271275 confers a (Thr-Ala) amino acid change in the protein structure and has previously been associated with early-onset obsessive-compulsive disorder in some American families in a genome-wide linkage scan [19].
The concept of external criticism has been associated with different aspects of Obsessive Compulsive phenomena.
PD is characterized by loss of dopaminergic neurons in the mesolimbic and mesocortical networks, and treatment with DA agonists has been associated with reward-seeking behaviors such as PG, compulsive shopping, and disinhibition [ 42].
Infection with T. gondii has been associated with some psychiatric disorders including schizophrenia [ 10- 12], personality disorders [ 13], and obsessive-compulsive disorder [ 14].
Obsessive compulsive disorder (OCD) is one of the most common psychiatric chronic disorders (prevalence 2 3%) and has been associated with various neurocognitive impairment, including visual memory function.
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