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These specific cytokines were chosen since IFN-γ serves as a useful proxy for Th1 responses, as well as being essential for immunity, while IL-4 is the prototypical Th2 cytokine and has been associated with active TB.
Previous work by our group has shown that active immunization with recombinant α-syn ameliorates α-syn related synaptic pathology in a tg mouse model of PD [17], however given the common immunological problems that have often been associated with active immunization we chose to pursue a passive immunization protocol for this study.
COPD has been associated with active tobacco smoking (attributable risk estimates in the range of 45% (UK) and 50% (US) among adults) [15], [16], however, chronic bronchitis and less frequently emphysema are also observed among lifetime nonsmokers (chronic bronchitis prevalence among nonsmokers varies across populations 6.3 12.1% [17], [18]).
Lower serum IFN-γ levels have been associated with active SSc [ 41].
LincRNAs have been associated with active transcription in regions of transcriptional elongation [ 42].
Recently, alpha power has been associated with active inhibition of external stimuli in a variety of tasks [ 41].
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Additionally, these deficits appear to be associated with active disease activity.
We postulated that phasic brain activity would be associated with active pedaling, consistent with a cortical role in locomotor tasks.
High levels of anti-BAFF were associated with active disease.
In eukaryotes, histone H3 trimethylated at lysine 4 (H3K4me3) is associated with active chromatin and gene expression.
Two domains of EBS and SHL bind distinct chromatin modifications that are associated with active and repressed chromatin.
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