Sentence examples for been associated to improved from inspiring English sources

Optimism, a personality trait defined as holding general positive beliefs regarding the future, has been associated to improved physical health and longevity.

SSTR2 expression has previously been associated to improved survival with neuroendocrine tumors [23] and childhood neuroblastomas [24], suggesting a potential role for SSTR2 as a tumor suppressor.

In contrast, HDAC 1 expression in breast cancer is associated with estrogen receptor/progesterone (PR) expression at the earlier stage of disease (T as well as N classifications) and improved patient survival response to tamoxifen (Bicaku et al. 2008), and HDAC 6 expression is associated to improved patient survival (Zhang et al. 2004).

These two tests could also be associated to improve diagnosis reliability.

Angiogenesis and apoptosis are primordial features of malignant tumours, constituting attractive therapeutic targets; drugs that inhibit angiogenesis or promote apoptosis could be associated to cytotoxic agents to improve antitumoral therapy.

This finding has implications for therapeutic response, wherein the establishment of senescence has been associated with improved response to therapeutic approaches [61], and suggests that somatic loss of RB in tumors could contribute to ultimate tumorigenic outgrowth of the cell population.

HER-2 overexpression has been associated with improved response to doxorubicin-based chemotherapy [ 36- 40].

In other disease sites, metformin use has been associated with improved response to chemotherapy [ 15], as well as improved outcomes after treatment [ 16– 16].

30 Serum levels of the chemokines IL8 (CXCL8) and IP-10 (CXCL10) are elevated compared with normal controls and increased levels are associated with higher HCV viral levels and disease activity while lower levels have been associated with improved response to combination therapy.

The polyglutamation of methotrexate (MTXglu) is an intracellular mechanism that retains the drug and enhances target enzyme inhibition within the folate pathway [ 20], and high concentrations of "long chain" methotrexate polyglutamates (MTXglu3-5) have been associated with improved response to the drug in adults with rheumatoid arthritis [ 21].

Inflammation on MRI has been associated with an improved response to TNF-inhibitors 39 and satisfies ASAS recommendations for the treatment of axSpA with TNF-inhibitors.