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Elevated dietary cholesterol has been associated to excess risk of several cancers (Hu et al, 2011).
Inadequate medication adherence (which includes three major components: persistence, initiation adherence and execution adherence) causes an increased financial burden for society as it has been associated to excess emergency care visits and hospitalizations, higher treatment costs and loss of productivity.
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Cognitive dysfunction has been associated to iron excess in brain regions in humans.
Most significantly, among members of the carnivora, the shift from mitochondrial localization to peroxisomal localization in the lineage leading to the Giant panda, a strict herbivore, has been associated to an excess of non-synonymous changes in the region coding for the mitochondrial targeting signal.
Disruption of the ER structure and the presence of increased vesicles or small vacuoles and in some cases, electron dense granules have been associated to exposure of plant cells to excess (toxic) levels of heavy metals [ 70, 71].
The obesity-related cardiometabolic risk factors (i.e. abnormal lipid profile and insulin resistance) are associated to an excess of central adiposity in adults, but this association is not clearly established in pre-school children [ 18, 21].
"Not eating breakfast has been associated with excess body weight, especially among children and adolescents.
Abdominal adiposity has long been associated with excess caloric intake possibly resulting from increased psychosocial stress and associated cortisol dysfunction.
Weekend admissions have been associated with excess mortality.
Rough order-of-magnitude estimates at the end of the supplemental files suggest that in 2010, hypnotics may have been associated with 320 000 to 507 000 excess deaths in the USA alone.
In contrast, older adults who present with non-severe conditions have been associated with contributing to the excess demand for ED care, a prominent public health problem as defined by the Institute of Medicine in the landmark Report on the Future of Emergency Care [ 13].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com