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Especially the use of long-acting macrolides has been associated to development of resistance [ 1].
Inherited mutations of the BRCA2 gene have been associated to development of both ocular and cutaneous melanomas, in addition to the main predisposition to breast and ovarian cancers [ 12- 14].
HCV core protein has been described as a multifunctional protein that in addition to function in viral nucleocapsid formation, influences several cellular function, such as cell growth and death [ 21- 23], immune cells functions [ 24, 25] and its expression in transgenic mice has been associated to development of steatosis and hepatocellular carcinoma [ 26, 27].
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Components of this putative interaction network are associated to development, DNA repair, cell division, calcium release, cell death, and maintenance of cell integrity.
Several risk factors (RF) have been associated to the development of osteoporosis.
One of the signaling pathways often used as a paradigm is that involving the Ras proteins, whose mutation has been associated to the development of human cancer [ 10].
Alterations of the expression of endothelial Cx have been associated to the development of chronic and acute vascular inflammatory diseases [ 32].
In fact, variation in the TIMP2 gene has been associated to the development of COPD in two different populations [ 16, 17].
Moreover, cancer development has been associated to defects in all of them.
Conclusions: All four major CMV gB genotypes (gB1 4) can cause a congenital infection but none seems to be associated to the development and the severity of disease.
The latter was associated to the development of proteinuria and FSGS [ 29].
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