The kinetics of each variable, from day 1 to day 6 of mechanical ventilation, was assessed with each variable's slopes (rate of biomarker change per day), highest level and maximum amplitude of variation (Δ max).
We acknowledge that our conclusions are limited by the fact that similarities between genetic, acoustic and social variables were assessed with uni-variable indices (one set of genetic markers, fundamental frequency contours and grooming behavior).
FLAIR was assessed with the variable display method because no standardised methods are currently available for FLAIR display.
Drug response was assessed with four variables: tumour DS, ypT0, OS and RFS.
Current shift work was assessed with a binary variable (Yes/No).
Adherence to the DASH diet was assessed with an index variable (7).
Prior diagnosis of anxiety and diagnosis of depression by a medical professional were assessed with binary (Yes/No) variables.
Differences between categorical variables were assessed with the Chi-square test and continuous variables with the Mann-Whitney test.
Continuous variables were assessed with the Student's t test for normally distributed variables and the Mann-Whitney U test for nonnormally distributed variables.
