One of the agents, Mylotarg, has recently been approved for treating acute myelogenous leukemia and represents the first clinically approved mAb-drug conjugate for the treatment of cancer.
The FDA has approved bevacizumab to treat colorectal cancer, but it has not been approved for the treatment of ocular diseases; however, this drug is being tested clinically for treating age-related macular degeneration [ 25].
Clinically, metronomic S-1 dosing has been approved for the standard first- and second-line treatment of metastatic or advanced stage of colorectal (CRC).
Some of these have already been approved by the FDA for human use, and many are currently being evaluated pre-clinically or in clinical trials.
Additionally, suspended animation is now occurring in a university hospital in Pittsburgh, where a saline-cooling solution has recently been approved by the FDA to preserve the clinically dead for hours before resuscitating them.
Benzodiazepines (BZDs) are approved for treating clinically significant anxiety and insomnia.
Autologous cell-based tissue engineering (TE) techniques have been clinically approved for approximately 4 years in China, since the first cartilage TE technique was approved for clinical use by the Zhejiang Health Bureau.
The most common synthetic biodegradable polymers being investigated for tissue engineering applications are FDA approved, clinically used poly(α-hydroxy esters).
This finding may be clinically relevant because ertapenem is approved for treatment of peritonitis, abdominal infection, and complicated skin and soft tissue infections in patients with diabetes and because E. coli is the main species isolated in human infections and the main enterobacterial species that expresses these emerging extended-spectrum β-lactamases CTX-M (15 ).
The first calcimimetic drug is cinacalcet, a positive allosteric modulator of the CaSR that is approved for treating secondary hyperparathyroidism (HPT) in patients on renal replacement therapy and for some forms of primary HPT characterized by clinically significant hypercalcemia.
