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In our workshop, we explore four areas where evolution has directly and dramatically been applied in human activities.
VSOP has already been applied in human clinical studies in the context of MR angiography (Taupitz et al., 2004; Wagner et al., 2011).
This species is extensively used in the industrial production of amino acids, such as glutamate and lysine, which have been applied in human food, animal feed, and pharmaceutical products for several decades (Hermann 2003; Krämer 1994; Liebl 2005).
For the latter, integration of evidence across studies will most efficiently be accomplished using systematic review and pooled analysis methods, such as have been applied in human genome epidemiology reviews [ 46].
Cell sheets are tissue-like cellular monolayers, which have been developed as a new tool for regenerative medicine and have already been applied in human clinical studies (e.g., cornea reconstruction, the treatment of esophageal ulcerations after endoscopic submucosal dissection).
Their application is growing: minicircles have recently been applied in human iPS cell technology and are of great promise as a nonintegrating method in stem cell engineering in a clinical setting [ 18, 19].
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This strategy, known as spermatogonial stem cell transplantation, has been successful in mice and other model systems, but has not yet been applied in humans.
Similar experimental paradigms have been applied in humans for aversive auditory stimuli [ 27], and showed that AC is associated with greater sympathetic activation.
There are small molecular weight molecules with antagonistic effects on C5a receptors, but their pharmacokinetics characteristics are inadequately known, and they have only been applied in humans in very limited circumstances (rheumatoid arthritis) without clinical efficacy (Woodruff et al, 2011).
Results were discussed in the light of health behavior change models that are applied in human medicine.
Although animal studies on tooth regeneration have been very promising, much more research is needed until this can be applied in human.
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