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The rest of them (2,194 AR binding regions, about 33%) could be mapped to more than 50 kb away from the transcript starts or ends of known genes or to regions that have not yet been annotated to be associated with genes in the human genome.
Among them, 2,240 had been annotated to be one single protein class while the rest 648 targets have been annotated to be multiple protein classes.
That is, these 30 genes have already been annotated to be related to oral cancer.
Among the 4 hub genes, the three genes EGFR, PDGFRB, STAT5A have already been annotated to be related to oral cancer according to GeneCards (see Table 2).
Most of the microRNAs listed in Table 2 have been annotated to be related to HCC in The human microRNA disease database (HMDD) [ 66] (Additional file 7).
Despite this gene has not been annotated to be related to oral cancer in GeneCards, both STAT5A and STAT5B belong to the STAT5 family the aberrant activity of which has been found to be related to various cancers [ 19].
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Additionally, 40 unigenes were annotated to be involved in the biosynthetic steps from GGPP to taxol within 'diterpenoid biosynthesis' pathway.
One potential and partial taxol biosynthesis pathway in C. cladosporioides MD2 was speculated, and dozens of unigenes were annotated to be involved in taxol biosynthesis.
Based on the KEGG analysis, 40 unigenes in the C. cladosporioides MD2 transcriptome were annotated to be related to the fungal taxol biosynthesis, and were homologous to the genes for TS, T5αH, T13αH, and TBT, respectively.
All of these seven proteins are annotated to be bound by MSH2, RFC4 and MSH6.
In the S. gregaria database several ESTs were annotated to be involved in GPCR signaling pathways (GO: 0007186).
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been trained to be
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CEO of Professional Science Editing for Scientists @ prosciediting.com