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More than 2,500 mature human miRNA sequences have been annotated so far (http://www.mirbase.org) [ 3].
Interestingly, about 50% of the genes with anther-specific expression have not been annotated so far.
In contrast, when we looked at SNVs which had not been annotated so far ('unknown SNVs'), concordance rates below 55fold coverages were up to 30% lower than for 'known' loci (Additional file 1, Figure S4).
The majority of nTARs could not be assigned to particular genes, probably due to the fact that they either lack conserved orthologous genes in other species or these genes have not been annotated so far.
In addition, we were able to resolve the 5′- or 3′-arms of known miRNA genes in C. elegans and P. pacificus that have not been annotated so far (supplementary table S2, Supplementary Material online).
In fact it relies on SPs that are common to all taxa, and counts the number of independent sequences, all of which contain the same SP. The fact that no comparisons to known data-bases (other than the list of SPs) are being used has a conceptual advantage: new species may belong to novel families and orders that have not been annotated so far.
Similar(53)
Many plant PPR genes that have been functionally annotated so far, are involved in either male fertility restoration through modification or silencing of cytotoxic mitochondrial transcripts, or post transcriptional modulation of plastid gene expression or plant embryogenesis and other plant developmental processes [ 52].
The slight decrease in specificity probably implies the discovery of previously unknown epitopes in the tertiary structures, as the epitopes have not been fully annotated so far.
However, this gene was poorly annotated so far.
Furthermore, these regions are interesting for further research to understand the mechanisms of resistance to NCLB and diseases in general, because some of the genes identified were not annotated so far for these functions.
melD is found on the linear chromosomes of four Streptomyces species that have been sequenced and annotated so far.
Related(20)
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