There has been an increasing realisation that the NHS is in trouble, deep trouble," she said.
There has been an increasing realisation of cooperation in evolution, perhaps dating back to Maynard Smith and Szathmary [ 61]) and more recently [ 62] have discussed the 'major transitions in evolution'.
Running alongside this improvement in breast-cancer-specific survival has been an increasing realisation that preservation of the breast, without compromise on rates of local control, is important for quality of life.
There was an increasing realisation that by giving greater importance to our Islamic identity we could transcend and overcome the narrow sectarian and tribal divides that were widespread among us.
Allied to that, he said, was an increasing realisation that the experience that people have with their computers has become more important than the underlying chips and peripherals.
After the self-flagellation and scathing international condemnation - many said India had become the world's rape capital - there is an increasing realisation that rape is a deeply complex problem and blights all countries.
There is an increasing realisation that reducing the use of fluoroquinolones and third-generation cephalosporins (which have been associated with increased carriage of MRSA) in patient populations where MRSA is prevalent can be a useful control measure.
Moreover, gene dosage is recognised as important in tumourigenesis, and there is an increasing realisation that CNVs may not be just symptomatic of the cancerous state but may, in fact, be causative.
It is no surprise that South Africa dominates the health research publications from the WHO African Region, because there is an increasing realisation of the need to promote indigenous health research in the country.
There is an increasing realisation that copy-number variation, and in particular the loss of one copy of a gene from a diploid cell or organism, can have a significant phenotypic impact.
Whilst surgery to the breast itself is becoming more complex, surgery to the axilla is becoming less extensive as there is an increasing realisation that the main value of identifying axillary disease is not to enhance survival, or even local control, but to give prognostic information to guide adjuvant therapies.
