In fact, in the paper, authors state, "the overall state of mass balance of the ice sheet is affected by considerable uncertainties in bed topography and ice thickness".
Glacier response to a changing climate and its impact on runoff is understood in general terms, but model-based projections are affected by considerable uncertainties.
Existing methods, however, are affected by considerable uncertainties, with large variations between different estimates for the same eruption (for Eyjafjallajökull, see e.g., Woodhouse et al. 2013; Ripepe et al. 2013, Bursik et al. 2012; Gudmundsson et al. 2012).
However, CRP was measured as a secondary outcome measure in most of these studies (Table 2) and all studies were affected by considerable risks of bias (Fig. 2).
Whereas many programmes in Africa are affected by considerable loss to follow-up, 22 our programme uses a special counselling team on motorcycles to consistently track patients.
Moreover, drug trials for CL are challenging because the disease mainly occurs in remote areas; as a result, proper follow-up is problematic and many studies have been affected by a considerable number of loss to follow-up events.
Air quality monitoring is an essential task in indoor environments, which require particular attention especially if they are affected by a considerable flow of people, as in museum environments.
Even when performed by experts, the asynchrony detection based solely on the PAO and Flow/time tracings (i.e., on the waveforms commonly available in the ventilator screen) is affected by a considerable inter-observer variability [ 44].
