It has been advocated that, if a variable cannot reduce uncertainty by at least 50%%, it is unlikely that the predictor can serve as a valid surrogate, via concordance, for the score being predicted [ 15].
On this basis it has been advocated that clinically relevant interventions must have the ability to reduce hot flush activity by 50% or more [ 10].
Indeed, it has been advocated that changes in pleural pressure may be preserved, as lung compliance is also reduced in ARDS patients.
Propranolol and ibuprofen have both been advocated in reducing persistent erythema.
49 Tailoring the intervention also means providing participants with a range of exercise options, an approach that has been advocated to reduce drop out, 50 including among drug users.
Education of physicians has been advocated to reduce the level of inappropriateness.
Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonisation and infection.
Thus, PCI has long been advocated to reduce the incidence of BM development [ 2- 5].
Targeted chlamydia screening has been advocated to reduce chlamydia associated reproductive sequelae.
The use of IT has been advocated to reduce the occurrence of medication errors [ 4].
