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The consensus is that patients cannot be considered drug-resistant unless drugs known to be effective in cluster headache and belonging to at least three different pharmacological classes have been administered at a sufficient dose and for a sufficient time.
This means that, to account for the levels observed on Day 0, a similar dosage level should have been administered at a median of 21 days (interquartile range 17 24 days, whole range 11 29 days) before study entry.
A potential explanation for this observation is that AG1478 may have been administered at a suboptimal dose (250 nM).
A second factor that may explain the lack of an additional benefit with smectite is that it may not have been administered at a sufficient dosage.
In clinical practice and research investigation, TENS has been administered at a variety of intensities as well of threshold of stimulation, both for antalgic [ 13, 14] and relaxing purposes [ 15- 17].
Since July 1, 2006, TXA has been administered at a dose of 50 mg/kg tranexamic acid before cardiopulmonary bypass (CPB) and 50 mg/kg into the priming fluid of the CPB.
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These can be administered at a local pharmacy that gives vaccines.
HA-L or HA-I was administered at a ratio of 1: 1 to randomized selected participants.
The MDMA is administered at a controlled dose, with informed consent, using procedures for which we have gained ethical approval.
Mebendazole was administered at a dose of 50 mg both in immediate release tablet and colon-targeted tablets.
Microcystin-LR was administered at a dose of 10 μg/kg bw/day, ip for 14 days in male mice.
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CEO of Professional Science Editing for Scientists @ prosciediting.com