Whether aging itself promotes the clonal dominance of non-neutral mutations in spermatogonial stem cells remains to be addressed in experimental settings.
While some of the molecular events involved are well understood, many unanswered questions remain, which need to be addressed in experimental and clinical studies in order to advance care of the critically ill burn patient.
However, important issues in biology are addressed in experimental systems other than mammals, specifically in birds (Jarvis, 2004, 2007; Jarvis et al., 2005), fish (Fetcho et al., 2008), and flies (Kuo et al., 2006; Yu et al., 2006).
This may be due to the low sampling fraction and if so, it will persist as an issue needing to be addressed in experimental design even as the next wave of technology produces larger numbers of reads.
In the current special issue, this topic has been addressed in both experimental and clinical studies, in which biomarkers assessment under different brain damage conditions, affecting central or peripheral nervous system, has been investigated.
Questions about novelty, restoration, and convergence have been addressed in the context of experimental evolution [ 2– 4].
All these issues have been addressed in this study per improved experimental design and procedures as outlined in the Experimental Section.
To the best of authors' knowledge, the convex optimization approach for verify levels of ISPP has not been addressed in the open literature though experimental approaches could be investigated in industry.
The sequelae of hypoxia and reoxygenation have been addressed in vascular models, and some limited experimental evidence has addressed this question in RA synovium [ 112].
No specific experimental approach to the resolution of this issue has been addressed in the mammary scientific literature.
