Sentence examples for been a substantial problem from inspiring English sources

This would be particularly important because, at that stage, the coupling between transcription, splicing, and nucleocytoplasmic transport would not yet have been perfected, and leakage of (partially) unspliced transcripts into the cytosol would have been a substantial problem.

What is less clear is whether the trade imbalance will prove to be a substantial problem.

The recovery of the otters proved not to be a substantial problem for the Navy.

Fraud is a substantial problem, and the attitude toward it has changed little over the years, other editors say.

From a global perspective, right now we are building up a huge problem in the west with our net debt and this is a substantial problem for development.

Because of the high cost of so many films, many studios have been eager to thwart film piracy, which is a substantial problem for American films in Asia.

After one of the worst weeks of the four-month-long occupation of Iraq, the top American administrator here, L. Paul Bremer III, offered an impassioned defense of it today while acknowledging that "mistakes" had led to the deaths of innocent civilians and that finding the money to repair Iraq's crumbling infrastructure was a "substantial problem".

In one in four cases there was a "clinically important delay" before the patient was seen by a consultant, access to CT and MRI scanning is a "substantial problem" at many hospitals and in one in five hospitals "do not attempt resuscitation" orders were signed by "very junior trainee doctors".

"Discrimination continues to be a substantial problem for too many job seekers and workers, and we must continue to build our capacity to enforce the laws that ensure that workplaces are free of unlawful bias," the commission's chairwoman, Jacqueline A. Berrien, said in a statement.

"It's a substantial problem," Botstein recognized.

Neurological complications of paediatric cancers are a substantial problem.