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A lack of understanding of the molecular basis of this inhibition has been a major bottleneck in the development of next generation of drugs essential for targeting the mycolic acid component of mycobacteria.
The necessity to analyze large volumetric data sets accurately, efficiently, and in true 3D has been a major bottleneck in deriving reliable relationships between altered neuronal function and changes in spine morphology.
The ability to analyze large volumetric data sets accurately, efficiently, and in true 3D has been a major bottleneck in deriving robust relationships between altered neuronal function and changes in spine morphology.
Therefore, the slow learning speed of FNN has been a major bottleneck in different applications.
The diauxic metabolism has been a major bottleneck to complete conversion and efficient utilization of multiple substrates [ 63].
However, the high turnover of programme managers and policy makers in the provincial/district level has seemingly been a major bottleneck to long-term relationships and policy influence.
Similar(53)
For Windows users, viruses can also be a major bottleneck for online connections.
The station now is a major bottleneck that causes serious delays.
Our experiences show that the lack of women's involvement in the political process, both formal and informal, continue to be a major bottleneck in pushing FGM to the top of states' agendas.
Interference is a major bottleneck in wireless network design.
Within the PSP problem loop refinement is a major bottleneck.
More suggestions(17)
been a major stumbling block
been a major disappointment
been a critical bottleneck
been a major concern
been a major point
been a major story
been a major setback
been a major win
been a major advance
been a major pain
been a major donor
been a major league
been a major interest
been a major shock
been a genetic bottleneck
been a major target
been a major focus
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com