One factor that causes significant variation in PHT plasma protein binding is a low plasma albumin level (hypoalbuminemia), leading to an increased free PHT fraction, although other factors such as uremia or drug-drug interactions (e.g., inhibition of phenytoin metabolism by valproic acid) can also alter the free fraction of PHT [ 14, 15].
Another complicating factor is whether a low plasma concentration really is indicative of depletion and an insufficient antioxidant defense in critical illness.
It has been reported that a low plasma glutamine level at intensive-care unit (ICU) admission is an independent risk factor for mortality.
Plasma glucose concentrations may not be available during an event, but neurological recovery following the return of plasma glucose to normal is considered sufficient evidence that the event was induced by a low plasma glucose concentration.
Plasma glucose measurements may not be available during such an event, but neurological recovery attributable to the restoration of normal plasma glucose levels is considered sufficient evidence that the event was induced by a low plasma glucose concentration [ 5].
If the pharmaco-nutrition philosophy is applied, higher doses are usually given, although the rationale for doses beyond what may be needed to restore a low plasma concentration is purely hypothetical.
Clinical hypoglycemia is characterized by Whipple's triad, ie, signs and/or symptoms known or likely to be caused by hypoglycemia, a low plasma glucose level, and cessation of signs or symptoms after plasma glucose is raised.
Microwave plasma operating at low pressure is a low-temperature plasma due to the non-equilibrium state between the electrons and other heavy particles in the plasma space and full of active species.
The objective of this study was to determine whether a low plasma volume in formerly pre-eclamptic women and HELLP patients is associated with an increased risk for recurrent hypertensive complications in a next pregnancy.
> -wrap-foot> Continuous variables given as mean (range) and categorical data as counts In the PK experiments in mice, elimination half-life was 0.63 h and a low plasma clearance (CL = 7.85 mL min−1 kg−1) and low volume of distribution (V = 0.684 L/kg) after IV dosing of E7820 were observed.
