In contrast, at the Sausa site in Central highland Peru, there is a generalized increase in maize production and consumption along with a reduction in the consumption of tubers under the Inka regime [13], [22].
In pregnancies with PE, there is some evidence that in addition to the vascular changes in the uteroplacental unit there is a generalized increase in maternal arterial stiffness [6] [11].
There is a generalized increase in the variation of miRNA abundance with age, consistent with a generalized increase in stochastic dysregulation.
Interestingly, there was a generalized increase in the case load of other, non-franchised services as well, particularly child health (e.g., seasonal illnesses).
Similarly, there was a generalized increase in most chemokines and cytokines in the nasal epithelial basal cells following Poly IC stimulation compared with the bronchial epithelial cells.
Assessment of biochemical markers of bone turnover indicates that there is a generalized increase in bone resorption, and that there is a correlation between disease activity and the rate of systemic bone resorption.
Overall, there is a generalized increase in relative protein levels for a host of proinflammatory and antiapoptotic signaling intermediates (nonactivated and activated) in both transfected cells and patients' PBMCs carrying the C33Y TNFR1 mutation.
To summarize the results (Table 6), we found that in the acute phase of the model (Days 0 to 5), and before evidence of any cartilage lesions, there was a generalized increase in expression of both chondrogenic and fibrogenic genes in both tissue compartments (presumably a direct anabolic response to TGFbeta1 injection).
This is difficult to establish because there is a generalized increased risk of acute pancreatitis in patients with diabetes, obesity or hyperlipemia.
When assaying the expression of genes in cancer it is important to remember that there is often a generalized increase in mRNA production due to heightened cellular metabolism, and certain genes that are often used to gauge alterations in expression, such as the commonly used β-actin housekeeping gene, may also be affected [ 12].
It is thought to represent a generalized increase in substrate mobilization both for the placenta and the growing fetus.
