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The detection of the anatomy and physiology of the basal ganglia loop has been a critical step towards this aim.
Regardless of the mechanism, ligation of the two hairpins would have been a critical step for the creation of a proto-tRNA molecule, proto-anticodon loop and (possibly at a later point) the anticodon itself.
Given the adaptations of apicomplexans toward intracellular niches, the acquisition of a major epigenetic regulator that governs and faithfully affirms chromatin-silencing marks could have been a critical step by protozoans for parasitism in diverse hosts with increasingly complex immune systems.
Gain of the bi-tyrosine motif might therefore have been a critical step in the development of Vpx allowing multiple modes of binding SAMHD1 while at the same time resulting in loss of the Vpr capacity to cause cell-cycle arrest.
Clinical decision support (CDS) is regarded as one of the core functions essential to a modern Electronic Health Record (EHR) [ 1, 2], and the addition of CDS functionality has been a critical step in the evolution of EHRs from a primarily billing and documentation tool to a true patient care and population management tool.
Similar(54)
But such rules are a critical step.
"That's a critical step".
Effective border control is a critical step.
"This pension reform is a critical step in that process".
"This agreement is a critical step forward in building a sustainable future for all," he said.
That's a critical step to fulfilling our obligation to protect our children from climate change".
More suggestions(16)
been a critical aspect
been a critical requirement
been a critical building
been a monumental step
been a critical research
been a modest step
been a critical success
been a critical component
been a crucial step
been a critical piece
been a major step
been a critical emergency-brake
been a necessary step
been a critical element
been a key step
been a critical darling
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com