This is a comprehensive meta-analysis of cognitive interventions in Alzheimer's disease (AD), specifically examining efficacy of interventions compared to active and non-active control groups.
Essentially all major numerical output that is produced by a comprehensive meta-analysis was assessed during the validation.
The measures of clinical outcome and health care resource consumption were obtained from a comprehensive meta-analysis of clinical trials known to be free of major methodological flaws.
For present purposes, the effective population sizes were assumed to be approximately 11% of the calculated mean global census sizes (Supplementary Methods S1); this relationship is based on a comprehensive meta-analysis of data for 102 species of animals [8].
This finding is supported by a comprehensive meta-analysis of published and unpublished HFCs in animal populations (based on MLH, Hs, IR, d2 and standardised d2), which concluded that, generally, heterozygosity accounts for less than 1% of the variance in phenotypic characters associated with fitness [40].
The only way to resolve this issue is to conduct a comprehensive meta-analysis based on the data available from all relevant studies (published or otherwise).
This association was confirmed in a comprehensive meta-analysis of the effect of somatic p53 mutations on prognosis in breast cancer [ 8].
However, as lung cancer is rare in never smokers, this hypothesis is difficult to test and a comprehensive meta-analysis will be required to obtain a sufficient sample size.
As a result, we were able to conduct a comprehensive meta-analysis in which the number of studies was almost three times higher than in the previous analysis[48].
The aim of Table 1, and this section, is not to provide a comprehensive meta-analysis, but to highlight the breadth of outcomes and mechanisms personality has been linked to, but where evidence is available from meta-analyses to provide effect size estimates.
