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Particularly since 2005, when Hurricane Katrina scattered the city's population, the question of what defines New Orleans in the minds of its remaining citizens and the world beyond has been a central question here.
In this generation of American politics, how a man reacted to the war in Vietnam — what service he did or avoided, how he interpreted his responsibilities, whether he was serious about the relation between his own choices and his country's — has inevitably been a central question.
"What parents owe their children" has been a central question in America since the beginning of the Republic, Paula Fass writes in "The End of American Childhood: A History of Parenting from the Frontier to the Managed Child" (Princeton) — much more so than what children owed their parents.
Protein complexes play a major role in transducing information from outside the cell into instructions for growth and survival, and understanding how these complexes relay and shape intracellular signals has been a central question in signaling biology.
The cause and mechanisms of the striking alteration of plant genomes after allopolyploidization has been a central question in allopolyploid genome evolution.
How ATP-dependent physical movements within hexameric helicases are coupled to DNA binding and unwinding has long been a central question in the field (Singleton et al., 2007; Enemark and Joshua-Tor, 2008; Lyubimov et al., 2011).
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It's a central question about performance.
There's always going to be a central question too.
Rudd: This is a central question in this election.
[4] How names attach to things is a central question in linguistics and philosophy.
The exact cause is a central question the multiple inquiries will tackle.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com