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Previous research, however, was conducted utilizing bedtime dosing.
A time-adjustable pulsatile release system (TAPS) containing ketoprofen (KF) as an active pharmaceutical agent was developed having been designed for bedtime dosing and releasing drug in the early morning to control the symptoms of rheumatoid arthritis (RA).
A novel verapamil chronotherapeutic oral drug absorption system (CODAS Verapamil) designed for bedtime dosing and with controlled onset and extended-release properties was evaluated in 257 patients with mild-to-moderate essential hypertension in an 8-week, double-blind, placebo-controlled trial.
The present protocol describes a trial to test the efficacy of bedtime dosing of the ACE inhibitor enalapril on night time blood pressure and left ventricular mass in patients with type 1 diabetes.
Possibly, other studies have failed to document an effect of melatonin on LH because bedtime dosing or use of higher doses creates 24-hour melatonin profiles less similar to those produced by a natural winter photoperiod.
The ease of once-daily bedtime dosing is likely to improve patient compliance over a three times daily dosing regimen, and it is likely to be of great benefit in the clinical treatment of pain associated with post-herpetic neuralgia.
Similar(51)
Some patients require continuous overnight drip feeds or a bedtime dose of cornstarch in order to control their tendency to develop hypoglycemia.
Eighteen healthy men received single bedtime doses of suvorexant 20 mg, zolpidem 10 mg, or placebo in a double-blinded, randomized, balanced 3-period crossover study.
A recommended dosing strategy is to start with a bedtime dose of 3 mg and then to increase the dose by 3 mg every four nights until pain relief is obtained, setting 24 mg as the upper dose limit.
Many other agents that have been reported to effectively treat HH include bedtime doses of caffeine (40 60 mg tablet, or as a cup of coffee), indomethacin, flunarizine, tricyclic antidepressants, verapamil, prednisone, topiramate, gabapentin, melatonin, benzodiazepines, pregabalin and acetazolamide.
Although it is not available in the United States, flunarizine has yielded good results in several controlled trials and has a proven efficacy (5 mg bedtime dose) in reducing headache frequency and headache duration.
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