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In a student's language, It doesn't make sense for one of them [that is, one of the traits] to become fixed, because when I think of something becoming fixed in a population, it becomes that way because it's an advantage.
It doesn't make sense for one of them [that is, one of the traits] to become fixed, because when I think of something becoming fixed in a population, it becomes that way because it's an advantage.
Because deleterious mutations have a vanishingly small probability of becoming fixed in a population, most substitutions (i.e., fixed mutations) would be neutral.
Indeed mathematical models show that a neutral allele arising by mutation has a very low probability of becoming fixed in a population; the larger the population, the lower the probability of fixation.
Since some therian mammals demonstrate suppression of the dorsal rib head (Table 2) and others demonstrate suppression of the ventral rib head (Table 2) it is not clear whether complete suppression of the lumbar ribs in therians is due to both of these traits becoming fixed in a common ancestor or due to a separate set of changes.
The probability of AT → GC substitutions becoming fixed in a genomic region through gBGC depends both on the rate of recombination and on the conservation of recombination activity for a long period of time.
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Under neutral conditions Ka/Ks is equal to 1, i.e., mutations occur randomly and the probability of a nonsynonymous mutation becoming fixed in the population is equal to that of a synonymous mutation.
For a diploid population of size N, a neutral mutation has a probability of 1/2 N of becoming fixed in the population.
Since favorable alleles have a lower chance of becoming fixed in allopolyploids than diploids [ 6], drift could have resulted in losses of innate immunity alleles in the Polydicliae and Suaveolentes lineages.
This is largely due to specific sites becoming fixed in the genome that perform functions associated with an improved fitness.
Based on this, the mutation to alanine was expected to result in weaker binding to the peptidases due to looser packing of L2 with the more flexible L2 loop incurring a greater entropic penalty in becoming fixed in the complex.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com