Clues to the type of aggregation formed by a protein could be found in the pathway the protein follows in becoming an aggregate.
For example, in LCDD, the formation of fibrils may be avoided due to the formation of intermediates that lead to aggregate formation in an off-pathway fashion [ 27]. Figure 8 shows a model of the various misfolding pathways a protein could follow on its way to becoming an aggregate.
It is also possible that factors required for UPS activity, such as ubiquitin ligases/proteases or proteasome activators, are becoming sequestered in aggregates during aging and retrieved from such aggregates by elevated disaggregation.
Urbanization, the process of becoming urban, reflects aggregate population growth in cities through either natural population increase or migration (Galea and Vlahov 2005) and is inextricably linked with development.
Now offering additional video content from Hulu and Vimeo, artist information from IMDB, audio from Rdio, and more, Onesheet is becoming a flexible resource for aggregating the Web services that make the entertainment industry tick and allow them to put their best face forward for public viewing and consumption.
Unbound aggregates are becoming increasingly scarce and expensive due to the loss of rock quarries and gravel mines to other land uses; therefore, it is important to engineer and optimize aggregate gradations for the targeted end-performances.
Following hydrogen reduction, metal ions in the precursors are reduced to zero-valence metals and aggregate until becoming nanoparticles resulting from steric confinement by the polymer structure.
Fan votes will count toward the outcome of the show, with the aggregate audience becoming a "fifth judge," along with the three regular judges and a weekly guest judge who joins the cast.
With ageing, amyloid peptides accumulate and aggregate, eventually becoming deposited in parenchym and vasculature, even in cognitive normal individuals as is emerging from clinical imaging studies.
Lerner can write a novel, set in the present, that deals with the subject head-on, but only by becoming essayistic, journalistic (the narrator is aggregating news stories in his head; he is neither evacuating a hospital nor being evacuated himself), and, even then, only amid the heaviest weather yet visited on New York City this century.
