Sentence examples for becomes unresponsive to from inspiring English sources

In brief, after one orgasm a male becomes unresponsive to sexual stimulation and cannot begin to build up another excitement phase until some period of time has elapsed, but females are physically capable of repeated orgasms without the intervening "rest period" required by males.

Studies in rodent models revealed a peculiar feature of hepatic insulin resistance, in which hepatic glucose metabolism becomes unresponsive to insulin but hepatic lipogenesis continues unabated, recognized as selective hepatic insulin resistance (Brown and Goldstein, 2008, Li et al., 2010b, Cook et al., 2015).

During treatment, cells susceptible to chemotherapy are killed and generally a few cells in the tumor remain and become resistant to drugs; these resistant cells multiply and the tumor eventually becomes unresponsive to treatment.

Based on clinical investigation, observation, and work with animal models, β-cell decompensation progresses over five stages as shown in Table 1. 10 Ultimately, genetically prone individuals with progressive β-cell dysfunction become exposed to an ambient state of chronic hyperglycemia, which becomes unresponsive to the pharmacologic actions of OADs.

Data obtained from the C/EBPβΔuORF homozygous mice showed that the C/EBPβ isoform production becomes unresponsive to extracellular stimuli, such as lipopolysaccharide treatment, which normally increases the LIP to LAP ratio 8. Furthermore, ablation of uORF initiation prevented the physiological induction of LIP during liver regeneration.

The number of patients with advanced heart failure that has become unresponsive to conventional medical therapy is increasing rapidly.

Peng et al. use a genetic method to show that a transcriptional regulator called Satb1 generates this bistratification: in its absence, ooDSGCs lose their ON arbor and become unresponsive to light-on stimuli.

Depending on the interparticle distance and angle of incidence, the cylinders yield total neutrality (or invisibility); they experience no force and become unresponsive to the transfer of the EM linear momentum due to multiple scattering cancellation effects.

But by the 1990's the ownership and management of the Mayfair had changed, and Mr. Maccioni said they had become unresponsive to his demands for repairs and the like.

Celiac disease patients administered fixed intradermal doses of Nexvax2 become unresponsive to the HLA-DQ2·5-restricted gluten epitopes in Nexvax2, but gastrointestinal symptoms and cytokine release mimicking gluten exposure, that accompany the first dose, limit the maximum tolerated dose to 150 μg.

To understand if GCSF alone could prime progenitors to become unresponsive to Flt3L-mediated cDC differentiation, consistent with the ex vivo results shown in Fig. 3b, progenitors were pre-treated with GCSF for 24 h prior to plating for differentiation in Flt3L.