A 69-year-old man was assessed 3 months post-fundoplication surgery for postprandial hypoglycaemia with neuroglycopenia that became progressively severe.
Externally, srn mutants exhibit a bent tail as early as 24 hpf, a phenotype that becomes progressively more severe (Fig. 1A), as well as a malformation of the hindbrain, which becomes apparent at 48 hpf (Fig. 1A, brackets).
Untreated mild heat illness (heat exhaustion) becomes progressively more severe (heat stroke).
Consistent with a model in which muscles constrain growth of the glands, we observed that the gland phenotype becomes progressively more severe as animals develop.
However when the temperature is shifted to 28°C during third instar larval development, there is a loss in amplitude of the EJPs that becomes progressively more severe the earlier that the shift is made.
As the disease progresses, this distance becomes progressively shorter, and in later stages the pain becomes severe and present even at rest.
These defects became progressively more severe with deletion of more modules from CipA and most severe for the CipA-ΔCBM-1 and CipA-ΔCBM-2 strains, in which the CBM is deleted.
Scanning electron microscopy revealed that, at the highest stresses studied, surface cracking occurred, which became progressively more severe as the time of treatment increased.
Central sensitization could become progressively more severe over time and, by an imbalance between the inhibition and the facilitation of pain dynamics, might contribute to chronification phenomena, interictal CA and probably pain perception abnormalities.
As expected, these mice begin to show mild spinal kyphosis and reduced body weight by 4 weeks of age, both of which become progressively more severe over time.
